礼来(LLY)值得长期买入,理由是其GLP-1市场领先地位、下一代药物管线(retatrotide)以及多元化的医疗健康业务组合。
逐段跳播
现在我要转向一个完全不同的板块,也就是医疗保健板块。我要谈的是礼来。同样,这可能并不是许多投资者此前会关注的名字,除非你过去几年一直在跟踪医疗保健和制药板块,赶上GLP-1的热潮。
Okay , now I'm going to move on to a completely different sector, which is the healthcare sector . I will talk about Eli Lilly. Again, this may not have been a name that many investors were following, unless you were following the healthcare and pharmaceutical sectors until the last couple of years, with the GLP-1 boom.
要知道,礼来是历史最悠久的持续经营的制药公司之一。礼来成立于1876年,150年来一直是全球最大的制药公司之一,历史上最广为人知的是生产胰岛素。事实上,它是20世纪20年代第一家商业化生产胰岛素的公司。
Bearing in mind that Eli Lilly is one of the oldest continuously operating pharmaceutical companies. Founded in 1876, Eli Lilly has been one of the world's largest pharmaceutical companies for 150 years, historically best known for producing insulin.
In fact, it was the first company to produce insulin commercially in the 1920s.
但当然,礼来的增长,尤其是过去两年的增长,源于其在GLP-1药物上的成功,比如用于2型糖尿病的Mongaro和用于肥胖症的Zippon。
But of course, Eli Lilly’s growth, especially over the past two years, is due to its success with GLP -1 drugs, such as Mongaro for type 2 diabetes and Zippon for obesity.
我想强调,这家公司在医疗保健板块实现了业务多元化,从肿瘤药物到免疫治疗药物,一直到靶向药物……礼来多年来治疗了许多神经系统疾病,并在这些领域保持领先地位。这是其增长故事的一部分,尽管市场和投资者尤其关注GLP-1这一方面。
I would like to emphasize that this company has diversified its activities in the healthcare sector, from oncology drugs to immunotherapy drugs, all the way to targeted drugs...
Eli Lilly has treated many neurological conditions for many years , and has remained a leader in these industries. This is part of its growth story, although the market and investors are particularly focused on the GLP-1 aspect.
Terziopatide是Manjaro和Zipbound的关键成分,在其类别中脱颖而出,成为最佳选择,表现优于诺和诺德的Ozembeek和Wegovi。
Terziopatide , the key ingredient in Manjaro and Zipbound, emerged as the best choice in its category, outperforming Novo Nordisk's Ozembeek and Wegovi.
礼来成功占据了很大的市场份额,如今是该领域的领先公司,领先于其竞争对手。今年4月,礼来获得了Zybound的批准,这是一种口服GLP-1药物,这一点非常重要。注射类药物的用途有限,因为无论效果多好,一些患者都拒绝开始或继续自行注射,而片剂则完全消除了这一障碍。
Eli Lilly has managed to capture a large market share and is now the leading company in this field, ahead of its competitors. In April of this year, Eli Lilly received approval for Zybound, an oral GLP-1 drug, which is very important .
Injectable drugs have limited uses, as some patients refuse to start or continue self-injection, no matter how effective it is, whereas the tablet completely removes this obstacle .
Zipbound尽管上市仅几个月,就已经广受欢迎。它们约占美国所有新服用GLP-1药物患者的30%。因此,随着这些新产品的推出,它们正在迅速抢占市场份额。
Zipbound, despite having been launched only a few months ago, is already enjoying widespread popularity. They represent approximately 30% of all new patients taking GLP-1 medication in the United States .
Therefore, they are rapidly gaining market share with these new launches.
礼来最值得关注的重要进展之一是接下来会发生什么,因为当然,在这个领域,当你推出一款成功的新药时,市场都在关注接下来会发生什么。你的下一代产品是什么?对礼来来说,是一款名为retarotide的药物。
One of the most important developments to watch with Eli Lilly is what happens next, because of course in this field, when you launch a new and successful drug, the market is watching what happens next.
What is your next-generation product? Well, for Eli Lilly, it's a drug called retarotide.
这款药物主要通过同时激活三种不同的代谢激素受体起作用,而不是像其两款主要药物Mongaro和Zippon那样只激活两种,目前已在五项处于最后阶段的独立临床试验中进行了测试。
This drug primarily works by activating three different metabolic hormone receptors simultaneously, instead of just two in its two main drugs, Mongaro and Zippon, through five separate clinical trials in their final stages so far.
Ritatrotide取得了整个这一药物类别迄今报告的最强疗效数据。一项试验显示,在调整安慰剂后,体重减轻约27%。这远远超出了当前GLP-1药物所能提供的效果,此外还在血糖控制、心血管风险,甚至其他相关疾病患者的关节疼痛方面带来了实实在在的改善。
Ritatrotide has achieved the strongest efficacy data reported to date in this entire drug class . One trial showed a weight loss of approximately 27% after adjusting for the placebo.
This goes far beyond what current GLP-1 drugs offer, in addition to real improvements in blood sugar control, cardiovascular risk , and even joint pain in patients with other related conditions.
因此,礼来将在2027年第一季度提交retatrotide的上市批准申请。我看到的华尔街预测显示,到2030年retatrotide的年销售额将接近40亿美元。这很可能是一个保守的估计。
Therefore, Eli Lilly will be submitting an application for approval of retatrotide in the first quarter of 2027. I have seen Wall Street estimates that suggest retatrotide sales will reach nearly $4 billion annually by 2030. This is probably a conservative estimate.
此外,礼来正在迅速扩大其胰高血糖素样肽-1(GLP-1)受体激动剂的产品线。Mongaro最近被列入中国医保药品目录。Mongaro在美国以外的收入增速如今已快于其在美国的收入,尽管礼来在所有GLP-1处方药和患者服用的药物中占据最大份额。
In addition, Eli Lilly is rapidly expanding its product line of glucagon-like peptide-1 (GLP-1) receptor agonists . Mongaro has recently been added to the list of medicines covered by health insurance in China.
Mongaro's revenues outside the United States are now growing at a faster pace than its revenues in the United States, although Eli Lilly holds the largest share of all GLP-1 prescription drugs and medications taken by patients.
这项业务仅在上个季度就创造了230亿美元的收入,同比增长约50%。其中约一半的收入来自GLP-1产品。至于今年春天获批的GLP-1诱导剂Zippond,它在上市的第一个季度就创造了约1亿美元的收入。
This business generated revenues of $23 billion in the last quarter alone, an increase of approximately 50% year-on-year . Approximately half of these revenues came from GLP-1 products.
As for Zippond, a GLP- 1 inducer that was approved this spring, it generated revenues of approximately $100 million in its first quarter on the market .
然而……我们仍处于起步阶段。所以,如你所知,GLP-1产品领域取得了巨大的成功,下一代候选产品也非常有前景。与大多数医疗保健公司相比,这是一只高估值股票。市盈率远高于我们通常从竞争对手那里看到的水平。
但这实际上归结于我们所看到的公司增长故事的转变。
And yet...we are still at the beginning. So, as you know, there is tremendous success in the field of GLP -1 products, and very promising candidates for the next generation. This is a high-value stock compared to most healthcare companies.
Price-to- earnings multiples are much higher than what we typically see from competitors. But this actually comes down to what we've seen in terms of how the company's growth story has transformed.
我想重申,这是该领域历史最悠久的制药公司之一。他们在GLP-1产品之外拥有一个非常赚钱且有吸引力的投资组合。GLP-1的举措无疑重估了这家公司和这只股票。我认为它仍然是一家非常适合长期买入并持有的优秀公司。
一个多世纪以来,他们一直以某种形式向股东分配利润。
I would like to reiterate that this is one of the oldest pharmaceutical companies in this field. They have a very profitable and attractive investment portfolio outside of GLP-1 products.
GLP-1's actions have certainly revalued the company and the stock. I think it's still a really great company to buy and hold for the long term. They have been distributing profits in one form or another for more than a century now.
因此,在我看来,礼来股票绝对是一只值得买入并持有的有吸引力的股票。我的意思是,当你看到它时,鉴于其业务增长和股价的规模,你可能会以为他们在卖图形处理器。但没错,这又是一个AI成功故事之外的名字。
Therefore, Eli Lilly stock is definitely an attractive stock to buy and hold in my opinion. I mean, when you look at it , you might think they're selling graphics processing units given the size of the business growth and the stock.
But yes, this is once again one of those names outside of an AI success story .
当然,你的主要竞争对手之一诺和诺德表现不佳,这无疑是有帮助的。难道不是吗?在这样一个增长环境中,此前曾是领导者的主要竞争对手表现不佳。这有助于礼来继续保持表现并快速增长。
Of course, it is certainly helpful that one of your main competitors, Novo Nordisk, is not performing well. Isn't that so? In such a growth environment , the main competitor, which was previously a leader, did not perform well.
This helps Eli Lilly continue to perform and grow rapidly.
正如我提到 SoFi 时所说,它的市盈率高于其他公司,因为它是同类中最好的,也因为它持续增长。自由现金流预计将以快于营收增长的速度增长。因此,它的盈利能力在不断增强。凭借这些额外的现金流,它要么投资于下一个产品,要么通过股票回购或股息分配回报投资者。
这是一家管理出色的公司,它充分利用了这一积极势头。
As I mentioned regarding SoFi, its price-to- earnings ratio is higher than the rest because it is the best in its category, and because it continues to grow. Free cash flow was expected to grow at a faster pace than revenue growth.
Therefore, it is constantly becoming more profitable. With this additional cash flow , it either invests in its next product or rewards investors with share buybacks or dividend distributions.
It is an excellently managed company, and it has made the most of this positive momentum .
有趣的是,如你所知,礼来和最近更名为 Novo 的诺和诺德,从股价角度看,一直交易得相当接近。然后,当然,它们两家……这两家公司在 GLP-1 竞赛中非常接近。它们各自的 GLP-1 药物与身体相互作用的方式不同。
Interestingly, as you know, Eli Lilly and Novo Nordisk, which recently rebranded as Novo, have been trading , from a share price perspective, fairly closely together . Then, of course, both of them... the two companies were very close in the GLP-1 race.
Their respective GLP-1 drugs interact with the body in different ways.
但我们看到,一个季度接一个季度,礼来清晰的财务表现持续优于诺和。它们的执行策略完全不同。礼来花费了数十亿美元建设其国内制造基础设施。它努力保护自己的供应链,避免外部供应商的错误。
But we have seen, consistently, quarter after quarter, Eli Lilly's clear financial performance outperform Novo. The implementation strategies were completely different. Eli Lilly has spent billions of dollars building its domestic manufacturing infrastructure.
She has worked hard to protect her supply chain from the mistakes of external suppliers.
礼来随后能够非常迅速地获得市场份额,这是诺和极难追赶的。从有效性角度看,它的结果总体上更好。所以,这对两家公司来说当然都是一个增长故事,但我认为,如果我们看这个领域,礼来是更具吸引力的增长型竞争者。
Eli Lilly was then able to gain market share very quickly, something Novo found extremely difficult to catch up with. From an effectiveness perspective, its results were generally better .
So, it's certainly a growth story for both companies, but I think if we look at this area, Eli Lilly is the more attractive competitor for growth.
这是一个长期的故事。总之,它们的投资组合也多元化得多,拥有 GLP-1 范围之外的一系列其他增长导向型产品。
The story is long-term. In summary, their investment portfolio is also much more diversified with a wide range of other growth-oriented products outside the scope of GLP-1.
观察点
这个频道对 $LLY 的历次判断
The Motley Fool 在这只股票上只有这一条判断。